Tagln-creert2
WebOct 1, 2024 · WT and Pdgfra-KO primary adventitia cells were isolated from the thoracic aorta of mT/mG/GLI1 CreERt2 mice and mT/mG/GLI1 CreERt2 /PDGFRA fl/fl mice after tamoxifen treatment for 10 days. The trypsinized cells were suspended in sorting buffer (1X PBS, 1 mM EDTA, 25 mM HEPES, 1% FBS) by concentration of 7 x 10 6 cells/mL and then … WebResults indicate that TAGLN is a p53 and PTEN-upregulated gene, expressing higher levels in normal bladder epithelial cells than in carcinoma cells. Further, TAGLN inhibited cell proliferation and invasion in vitro and blocked tumorigenesis in vivo. Collectively, it can be concluded that TAGLN is an antitumor gene in the human bladder.
Tagln-creert2
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WebMar 21, 2024 · TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Peyronie Disease and Aortic Dissection.Among its related pathways are PDGFR-beta signaling pathway and Burn wound healing.Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding.An important paralog … Web图 2 Tagln Cre/+; Rosa26 tdTomato/+ 小鼠肺部tdTomato的表达情况。 Tagln Cre/+; Rosa26 tdTomato/+ 双转基因鼠，可在小鼠在肺血管平滑肌细胞中检测到tdTomato的表达。 图 3 Tagln Cre/+; Rosa26 tdTomato/+ 小鼠各组织中tdTomato的表达情况。TdTomato的表达在大脑，眼，心，肝，肺，肌肉，胰腺 ...
WebTransgelin. Transgelin is a protein that in humans is encoded by the TAGLN gene. [5] [6] [7] The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and ... WebThe expressions of TAGLN in colorectal carcinoma tissues, adjacent normal tissues, and LoVo cells were detected by the Western blot method. The recombinant plasmid pcDNA3.1-TAGLN was established and transfected into LoVo cells with the help of Lipofectamine™ 2000. At the same time, the TAGLN siRNA was transfected into LoVo cells in another group.
Web利用Cre-lox系统在小鼠体内实现对基因的时空特异性打靶（表达或敲除），原则上需要建立两种小鼠。. 首先，建立特异性Cre小鼠，该小鼠中的Cre重组酶由特定启动子驱动，可在特定细胞或组织或全身表达Cre重组酶。. Cre重组的特异性由驱动Cre的启动子或增强子 ... WebNov 6, 2024 · Activation of transforming growth factor beta (TGFβ)/Smad signaling, for example, has been found to induce TAGLN expression in human bone marrow-derived …
WebTransgelin (TAGLN, also named SM22) is an actin-associated protein and affects dynamics of actin filaments. Deregulation of TAGLN contributes to the development of different cancers, and it is commonly considered to be a tumor suppressor. TAGLN is usually downregulated in prostate cancer; however, the detailed functions of TAGLN in prostate ...
WebMay 18, 2024 · At 20 dpf, tagln-positive MCs with the typical shape of arterial VSMCs had lost abcc9 expression, which however remained in capillary pericytes ... We also analyzed a newly generated Abcc9-CreERT2;R26-mTmG mice and obtained analogous results to those described for Kcnj8-CreERT2;R26-mTmG mice. innovations it and technologiesWeb南模生物. Language: 中文 . English; 日本語; 한국어; 账户设置; 退出 innovation smart cabinetWebTagln-CreERT2小鼠与FloxP小鼠交配后，在Cre特异表达的组织或者器官或细胞中，两个FloxP位点间的外显子或元件将被删除，达到条件性敲除或过表达的目的。可用于心血管 … innovations manufacturing and distributingWebEndocrine system. Nervous system-Others. Hindbrain, especially the dorsal motor nucleus of the vagus nerve, visceral motor neurons and gill motor neurons located in the parasympathetic nerve, nodal sensory ganglia and solitary bundle nucleus cells; adult mice also have Cre activity in the adrenal gland with induction. No. modern day examples of romanticismWebSep 4, 2024 · Pdgfra-expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues.To determine lineage potential, we generated Pdgfra rtTA knockin … modern day fact fileWebMar 21, 2024 · Also known as. SM22; SMCC; TAGLN1; WS3-10; SM22-alpha. Summary. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. innovationsmanagement fraunhoferWebJul 1, 2024 · AbstractTransgelin (TAGLN, also named SM22) is an actin-associated protein and affects dynamics of actin filaments. Deregulation of TAGLN contributes to the development of different cancers, and it is commonly considered to be a tumor suppressor. TAGLN is usually downregulated in prostate cancer; however, the detailed functions of … modern day explorers and adventurers