WebNov 25, 2024 · Netrin-1 to -4 are composed of one N-terminal domain VI, a positively charged C-terminal domain and three laminin V-type epidermal growth factor (EGF) domains with the same characteristic number and spacing of Cys residues as observed in laminins. 8,9 Unlike the structures of netrin-1, -3, and -4, full length netrin-5 comprises three V … WebNetrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling by: Ahmad Abdullah, et al. Published: (2024-04-01) Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma by: Thomasson Marcus, et al. Published: (2012-05-01)
Primary Antibodies for Diverse Immunoassays: i.a. IHC - dianova
Human recombinant BMP4 (#120-05), BMP6 (#120-06), BMP9 (#120-07), and mouse noggin (#250-38) were purchased from PeproTech Nordic (Stockholm, Sweden). Human recombinant netrin-1 (#6419-N1) was obtained from Bio-Techne Ltd. (Abingdon, UK). The antibodies used in this study are listed in … See more Mouse embryonic fibroblast (MEF) lines established in our laboratory according to the 3T3 protocol22 were cultured in Dulbecco’s modified Eagle’s medium (DMEM) (Sigma-Aldrich Sweden AB, Stockholm, Sweden) … See more RNA extraction was carried out using a PureLink RNA Mini Kit (Invitrogen, Fisher Scientific GTF AB) with PureLink DNase (Invitrogen, Fisher … See more Cells were seeded at a density of 3,000 cells per well in a 96-well microtiter plate (#655090, Greiner Bio-One International GmbH, Monroe, NC, USA) coated with 0.1% bovine gelatin. After an overnight incubation, the cells … See more Lrig-triple FLOXed MEFs (Lrig1fl/fl;Lrig2fl/fl;Lrig3fl/fl) or Lrig-null MEFs (Lrig1−/−;Lrig2−/−;Lrig3−/−) with inducible LRIG1 or LRIG3 alleles26 were transfected using Fugene6 transfection reagent (Promega … See more WebOct 23, 2024 · Background Netrin-1, a secreted laminin-like protein identified as an axon guidance molecule, has been shown to be of critical importance in the cardiovascular system. Recent studies have revealed pro-angiogenic, anti-apoptotic and anti-inflammatory properties of netrin-1 as well as cardioprotective actions against myocardial injury in … trinitys doetinchem
Netrin-1 functions as a suppressor of bone morphogenetic protein …
WebBMP signals regulate developmental patterns and have important physiological roles in mature organisms. LDN193189 HCl has been used to reduce heterotopic ossification in mouse models. The role of BMP2 signaling in the growth and angiogenesis of non-small cell lung cancer (NSCLC) also suggests that LDN-193189 may be an effective lung tumor … WebNetrin-1 is a member of the laminin-like protein family and was initially identified as a potent chemotactic molecule involved in axonal guidance and cell migration during embryonic … WebNetrin-1 is o˝en highly expressed in cancer tissues (see, for example, the Human Protein Atlas [www.eot prl int a s.agor ]) and has been reported to promote tumorigenesis in a … trinitysanpedro.org